LaserVision

Treatment at a glance

20 minutes

Local anaesthetic

1-3 Weeks

Permanent

Stabilise keratoconus / prevent progression

During this procedure the superficial layer of epithelial cells is removed, and riboflavin (vitamin B2) drops are applied to the cornea followed by UV-A light.

This combination causes the corneal collagen to create more bonds between strands, making the structure stiffer and stronger. This process mimics the natural age-related changes in a healthy cornea.

CXL is useful in conditions such as keratoconus where the cornea may undergo a progressive thinning and steepening. As with all operations there are risks: the procedure is safe but there is a small chance of worse vision due to corneal haze, scarring or infection.

During this procedure the superficial layer of epithelial cells is removed, and riboflavin (vitamin B2) drops are applied to the cornea followed by UV-A light.

This combination causes the corneal collagen to create more bonds between strands, making the structure stiffer and stronger. This process mimics the natural age-related changes in a healthy cornea.

CXL is useful in conditions such as keratoconus where the cornea may undergo a progressive thinning and steepening. As with all operations there are risks: the procedure is safe but there is a small chance of worse vision due to corneal haze, scarring or infection.

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Treatment Benefits Benefits

What are the benefits of Corneal Collagen Cross-linking (CXL)?

  • Stabilise keratoconus / prevent progression
  • Improve corneal shape
  • Improve vision

How is it performed?

  • 1.Performed under local anaesthetic in sterile treatment room / operating theatre.
  • 2.Patient is laid flat on a bed or reclining chair.
  • 3.Sterile drape is placed and eyelid support inserted.
  • 4.Surface epithelial cells removed with alcohol and riboflavin (vitamin B2) eye drops put onto the eye. This allows the riboflavin to soak into the cornea.
  • 5.UV-A light is then applied to the eye for around 10 minutes.
  • 6.Topical anaesthetic and antibiotic drops applied.
Corneal Collagen Cross-linking (CXL)
LaserVision-FAQ-Main

CXL is usually recommended for patients who have evidence of progression of their keratoconus. This decision is made based on changes in vision, glasses or contact lens prescription combined with changes in corneal tomography measurements. CXL may also be used in keratoconus patients in combination with excimer laser treatment (Athens protocol) to help stiffen and regularise the corneal shape leading to improved vision.

Currently CXL is the only treatment that is proved to halt the progression of keratoconus. Several randomised control studies have shown that CXL stops the progression of keratoconus in around 90% of patients at 1 year after treatment with the benefit maintained at 5 years. Nearly 50% of patients also gained an improvement in corneal shape.

The most widely used treatment protocol is ‘epithelium-off rapid’ CXL which is a safe, more up-to-date adaptation of the original Dresden protocol and involves 30 minutes of UV light treatment. In the accelerated protocol treatment time is reduced to under 10 minutes.
In ‘rapid’ or ‘accelerated’ CXL, the fluence and illumination of the UV light can be altered to reduce the length of UV light exposure. Several clinical studies have shown these accelerated regimens are better tolerated, safer and just as highly effective.

It is possible to treat both eyes simultaneously on the same day. It is more common to treat one eye at a time with the second eye treated a few weeks later. It is common for there to be some discomfort in the treated eye for 2-3 days after the procedure and so some prefer to have one eye treated at a time. Everyone’s description of pain is different with some reporting minor discomfort and others significant light sensitivity and pain.

Patients are given several different drops after CXL treatment (antibiotic / anti-inflammatory / analgesia) which are to be used over the 2-4 weeks following the procedure. It is normal to feel some discomfort / light sensitivity over the first 2-3 days, but this should gradually settle. If there is any increasing pain or worsening vision, patients are advised to contact their surgeon / LaserVision office directly or visit their local A&E department. You are advised to rest / take time off work for the first week. Reading and watching TV will not harm your eye but you may find these activities uncomfortable in the first few days following treatment. Patients will be seen in the clinic one week post treatment.

CXL is a safe and highly effective treatment but any treatment has potential risks and complications. The eye needs time to heal and settle, and vision may be blurred for a few weeks. About 3% of patients may lose some vision due to corneal haze, scarring, corneal shape irregularity or infection. Without CXL treatment around 20% of patients will progress to require a corneal transplant in the future (DALK or PK).

Choosing the right vision correction clinic for your surgery is paramount. This is a life changing procedure after all, and you need to have complete trust in your surgeon and care team of professionals.

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Choosing the right vision correction clinic for your surgery is paramount. This is a life changing procedure after all, and you need to have complete trust in your surgeon and care team of professionals.

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